pI: 4.6805 |
Length (AA): 342 |
MW (Da): 39569 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
4 | 334 | 4tnd (A) | 155 | 463 | 19.00 | 0 | 1 | 1.15464 | -0.05 |
32 | 321 | 5lqf (A) | 1 | 289 | 53.00 | 0 | 1 | 1.55865 | -1.18 |
33 | 67 | 3hzt (A) | 74 | 108 | 34.00 | 0 | 0.48 | 0.398139 | 0.62 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_132867)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_27415 | cell division control protein 2 homolog |
Caenorhabditis elegans | CELE_F49C5.4 | Protein F49C5.4 |
Drosophila melanogaster | Dmel_CG4629 | CG4629 gene product from transcript CG4629-RE |
Echinococcus granulosus | EgrG_000930400 | serine:threonine protein kinase NIM1 |
Echinococcus multilocularis | EmuJ_000930400 | serine:threonine protein kinase NIM1 |
Homo sapiens | ENSG00000177453 | NIM1 serine/threonine protein kinase |
Loa Loa (eye worm) | LOAG_15879 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15185 | CAMK/CAMKL/NIM1 protein kinase |
Loa Loa (eye worm) | LOAG_15001 | hypothetical protein |
Mus musculus | ENSMUSG00000095930 | NIM1 serine/threonine protein kinase |
Onchocerca volvulus | OVOC11285 |
|
Schistosoma japonicum | Sjp_0054360 | expressed protein |
Schistosoma japonicum | Sjp_0054420 | Serine/threonine-protein kinase NIM1, putative |
Schistosoma japonicum | Sjp_0054370 | expressed protein |
Schistosoma japonicum | Sjp_0054400 | Serine/threonine-protein kinase NIM1, putative |
Schistosoma japonicum | Sjp_0133320 | expressed protein |
Schistosoma mansoni | Smp_094190 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.009565.00 | |
Schmidtea mediterranea | mk4.011025.00 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | NIM1 serine/threonine protein kinase | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 53.8% | 290 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 48.6% | 288 aa | Compounds | References |
Zea mays | Casein kinase II alpha | 332 aa | 26.0% | 308 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 44.5% | 290 aa | Compounds | References |
Schizosaccharomyces pombe 972h- | Casein kinase II subunit alpha | 332 aa | 25.5% | 302 aa | Compounds | References |
Rattus norvegicus | Jak1 protein | 210 aa | 26.0% | 215 aa | Compounds | References |
Patiria pectinifera | Cdc2 | 300 aa | 52.1% | 290 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 46.1% | 191 aa | Compounds | References |
1 literature reference was collected for this gene.